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The potential for transmission of infectious agents is a concern, however, and a recent publication outlines rigorous screening of stool donors blood and stool for common bacterial and viral enteropathogens (85). In one series, a standardized filtered, frozen, and then thawed preparation of stool from pre-screened universal donors showed cure rates equal to or better than those from patient-identified donors (103).

Of these 77 subjects, four developed an autoimmune disease (rheumatoid arthritis, Sjogrens syndrome, idiopathic thrombocytopenic purpura, and peripheral neuropathy) at some time after the FMT, although a clear relationship between the new disease and the FMT was not evident (101).